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Home > Products >  Reliable quality of on hot selling Enoxolone 471-53-4 global trader

Reliable quality of on hot selling Enoxolone 471-53-4 global trader CAS NO.471-53-4

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  • FOB Price: USD 400 /Kilogram Get Latest Price
  • Min.Order: 20 Kilogram
  • Payment Terms: T/T
  • Available Specifications:

    Pharm grade(20-100)KilogramPharm grade(100-500)Kilogramcometics grade(20-100)Kilogramcometics grade(100-500)Kilogram

  • Product Details

Keywords

  • Reliable quality of Enoxolone 471-53-4
  • global trader Enoxolone 471-53-4
  • Enoxolone 471-53-4 on hot selling

Quick Details

  • ProName: Reliable quality of on hot selling En...
  • CasNo: 471-53-4
  • Molecular Formula: C30H46O4
  • Appearance: White or almost white crystalline powd...
  • Application: An anti-inflammatory (topical). antit...
  • DeliveryTime: 30days
  • PackAge: 500g/bag,10kg/drum
  • Port: Tianjin or Shanghai
  • ProductionCapacity: 10 Metric Ton/Year
  • Purity: 98.0%-101.0%(dried substance)
  • Storage: Store in sealed containers at cool & d...
  • Transportation: by Air or by sea
  • LimitNum: 20 Kilogram
  • Total impurity: ≤2.0%
  • Any impurity: ≤0.7%
  • Heavl Metal: ≤10ppm
  • Sulphated Ash: ≤0.2%
  • Rotation :: +145° - +154°
  • Melting point:: 288-297℃

Superiority

【annual production】The annual production capability of the factory can reach to fifty tons.

superiority

1.we are manufacture and our production workshop had passed China GMP.

2.we can give you lowest price and best quality,only you can choose us.

3.Our government stipulates that licorice quota system is adopted for the export of licorice products, and our company has sufficient licorice quota every year.

4.We are only have Enoxolone GMP certification in china

5.we have Enoxolone DMF file

Reliable quality of  on hot selling Enoxolone 471-53-4 global trader

Enoxolone Basic information
Product Name: Enoxolone
Synonyms: 3.beta.-Hydroxy-11-oxo-12-oleanen-30-oicacid;3-beta-hydroxy-11-oxo-olean-12-en-30-oicaci;3-beta-hydroxy-11-oxoolean-12-en-30-oicacid;3-hydroxy-11-oxo-,(3.beta.,20.beta.)-Olean-12-en-29-oicacid;3-hydroxy-11-oxo-,(3beta,20beta)-olean-12-en-29-oicaci;3-Hydroxy-11-oxo-12-oleanen-30-oicacid;3BETA-HYDROXY-11-OXO-18BETA, 20BETA-OLEAN-12-EN-29-OIC ACID;3BETA-HYDROXY-11-OXO-18BETA-OLEAN-12-EN-30-OIC ACID
CAS: 471-53-4
MF: C30H46O4
MW: 470.68
EINECS: 207-444-6
Product Categories: Pentacyclic Triterpenes;Tri-Terpenoids;Inhibitors;Cosmetic Ingredients & Chemicals;Chiral Reagents;Heterocycles;-;Miscellaneous;Biochemistry;Terpenes;Terpenes (Others);Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 471-53-4.mol
Enoxolone Structure
 
Enoxolone Chemical Properties
Melting point  292-295 °C(lit.)
alpha  165 º (c=1, CHCl3,on dry ba)
Boiling point  492.11°C (rough estimate)
density  0.9967 (rough estimate)
refractive index  162 ° (C=1, MeOH)
solubility  Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.
pka pKa 5.56±0.1 (Uncertain)
form  Crystalline Powder
color  White to off-white
optical activity [α]22/D +170.0°, c = 1 in chloroform
Water Solubility  SOLUBLE IN ACETIC ACID
Merck  14,3590
BRN  2229654
CAS DataBase Reference 471-53-4(CAS DataBase Reference)
EPA Substance Registry System Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-(471-53-4)
Enoxolone Usage And Synthesis
Chemical Properties white or greyish-white crystalline powder
Uses An anti-inflammatory (topical).
Uses antitussive, antiinflammatory, antibacterial
Uses The aglycone of the triterpenoid Glyccyrrhizic acid.
Uses glycyrrhetinic acid is anti-irritant, anti-allergenic, anti-inflammatory, skin-lightening, and smoothing properties are attributed to this ingredient, which is also a carrier. It is the organic compound derived from glycyrrhizic acid or shredded licorice roots.
Definition ChEBI: A pentacyclic triterpenoid that is olean-12-ene substituted by a hydroxy group at position 3, an oxo group at position 11 and a carboxy group at position 30.
Anticancer Research Glycyrrhetinic acid in combinationwith etoposide inhibits thetopoisomerase 2α and inducesapoptosis
Cai et al.(2017)
Anticancer Research It was reported that GA at noncytotoxic concentrationshowed synergistic effect in combination with anticancer drug, etoposide (VP-16).Specifically, GA enhanced cytotoxicity through regulating topoisomerase II-αtargeted by etoposide. Also, GA sensitized the cells to etoposide through elevatingtopoisomerase II-α with a 2.4-fold rate at 12 h time point. From 12 to 48 h, GAhalved the expression of topoisomerase II-α and stimulated apoptosis, whichexhibited its antineoplastic effect. They reported that GA was more potentiallyeliminating the TNBC cells when compared with Glycyrrhizin Acid (Cai et al. 2017).

Details

Pionnier of Licorice Extract industry in China, Shaanxi Fujie Pharmaceutical co.,ltd has more than 25 years experience in the sector of licorice root extraction and provides high quality products to diverse industries. 

As an highly effeicient ingredient, licorice extract are widely used in  pharmaceutical, food, cosmetic, tobacco, dietary and healthy supplementproducts

Today our main products are:

  • Glycyrrhizic acid-based produts:

  • Enoxolone(18β-Glycyrrhetinic Acid)

  • Ammonium  Glycyrrhizinate (MAG)

  • Glycyrrhizic acid A 

  • Dipotassium Glycyrrhizinate (DPG)

  • Potassium Glycyrrhizinate 

  • Tripotassium Glycyrrhizinate (TPG)

  • Other licorcie extracts:

  • Licorice extract powder

  • Licorice liquid extract 

  • Licorice extract spray

  • licorice extract

  • Deglycyrrhizinised Liquorice Extract

  • Licorirce extract block

  •  

Our products are certified by GMPFSSC 22000, ISO 22000 in China and are registed in FDA in the U.S. 

We have built solid relationships with customers in China, Japan, Korea, North American and Europ and are always open for new international business opprtunities. 

 

Enoxolone is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid, which was obtained from the herb liquorice. It is used in flavoring and it masks the bitter taste of drugs like aloe and quinine. It is effective in the treatment of peptic ulcer and also has expectorant (antitussive) properties. It has some additional pharmacological properties including antiviral, antifungal, antiprotozoal, and antibacterial activities.

Enoxolone is an oleanolic acid from Glycyrrhiza that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

Basic Info

· Product Name: Enoxolone

· Resource: 100% licorice roots

· Raw Material: licorices

· Certificate: GMP 

· Shelf Life:24 moths

· Transport Package:  All Paper Drum

· Origin: Shaanxi , China

· Appearance: White or almost white crystalline powder.

· HS Code: 2938909030

Content: 98.0 per cent to 101.0 per cent (dried substance)

· Trademark: FUJIE

· Specification: 10KG/drum

· Molecular formula:C30H46O4

· Molecular weight:470.7

· CAS NO:471-53-4

· Action and use:Treatment of benign peptic ulcer disease

Grade:European Pharmacopoeia 9.0

structural formula    

Solubility:Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.It shows polymorphism .

 

 

 

 

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